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Abgentis News

  • Low spontaneous resistance development to GYR12/colistin combination

    Abgentis continues to explore the potential of the novobiocin-analogue GYR12 in combination with antibiotic potentiators such as colistin, polymixin B or pentamidine.

    At pharmacologically achievable exposures GYR12/colisitin has broad-spectrum activity including E. coli, K. pneumoniae, A. baumannii and P. aeruginosa.

    We have recently shown that spontaneous resistance frequency development to the combination is low e.g. <10e-9, consistent with suppression of resistance in use.

    The combination of GYR12 with a potentiator such as colistin or pentamidine has the potential to bring the GyrB/ParE targets into clinical use to treat drug-resistant Gram-ve bacterial infections.

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